Derek Lowe's commentary on drug discovery and the pharma industry. bicalutamide was found to be effective as an inhibitor of RdRp (docking score -8.7) by: This cattle dewormer is effective against a wide range of external and internal parasites in beef cattle and swine. There’s a newer study: The result is 6 times more death Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites. The preference for a vaccine rather than a therapeutic drug is not an arbitrary bias of “the powers that be”. Here are some common drugs that are safe for use in pregnant dogs: Thryoxine, used to treat hypothyroidism in dogs. No problem. It is going to take 10 years to recruit 80 patients? All dogs take this with no problems. https://www.microbe.tv/twiv/twiv-599/. The discussion in Antiviral Research Derek pointed us to reminded us that ivermectin is also a nonselective inhibitor of three important mammalian P-type ATPases (SERCA, Na+/K+-ATPase and H+/K+-ATPase) at the same concentrations it took to disable coronavirus. Testimony of Pierre Kory, MD at the Homeland Security Committee Meeting: Focus on Early Treatment of COVID-19, December 8, 2020 Equilibria) in the limits: Overall fatalities were 5/6ths lower, fatalities among those on ventilators were reduced by two-thirds. It may just be that Ivermectin is so cheap and widely accessible that they’re testing it as a low probability/high upside effort. I go back quite a ways with this compound, back to my graduate school days when several folks in my old research group were trying to complete a total synthesis of the compound. Made with real beef. https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v1?fbclid=IwAR0N6pVNnHBj2xE0p3r627PMQ6wzGh_1PeN03vO4x7ldFZO44WTcAycdoX4. That’s not because it hangs around in the blood in high concentrations for that long – the compound’s half-life is a few hours, and it’s extensively metabolized as it goes through the liver. Guidelines For Use For safe treatment with this medicine we recommend following these guidelines: Turtles apparently don’t pump the drug back out at all, and those dog breeds have picked up mutations in PGP (all that close breeding) that allow the drug to accumulate in the brain and set off severe neurotoxicity via those other ion channels. Update: there is a report, using data from a company that has a real-time hospitalization database, of a retrospective matched-control set of coronavirus patients receiving Ivermectin versus those that did not. So, can you derive anything from that report? DId you LOOK at the study? That’s different from e.g. Save my name, email, and website in this browser for the next time I comment. You stated that the normal dose of 12 mg to 18 mg wouldn’t provide enough blood concentration to be effective, something like 5 times the amount less than needed. But who am I? Gates foundation paid $19M to a French company Medincell for clinical trial. Barry, the great majority of coronavirus patients are not hospitalized, and the point of having a good medication is so they won’t need to be hospitalized. The drug is only by prescription so perhaps this is handled at the veterinarian level? https://trialsitenews.com/us-senate-hearing-explores-ivermectin-as-miracle-drug-for-covid-19-while-mainstream-media-outlets-ignore/………US Senate Hearing Explores Ivermectin as “Miracle Drug” for COVID-19 While Mainstream Media Outlets Ignore. By shopping online with Pet Shed you can be sure that your details are not compromised - we encrypt every transaction to the highest global standards.This site is secured by 256 bit SSL encryption. Thanks for this article and the comments from intelligent, trained, knowledgeable, experienced professionals. While other parasite medicines like ivermectin have been associated with many risks (particularly in herding breeds), fenbendazole appears to … https://bgr.com/2020/05/08/coronavirus-treatment-study-says-prostate-cancer-adt-can-save-men/. Yep… roughly 30 ng divided by MW bit under 1000 is around 40 picomol per ml, therefore around 40 nanomol per l, therefore around 40 nmol. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. As those letters to Antiviral Research note, ivermectin will start to hit other targets as you jack up the doses. Go to your local feed store. His most well known is: }, Are we off by five orders of magnitude or only a factor of fifty? But transmission of this coronavirus from the reservoir to humans is very rare. Anyway, it was referred to by some of us as “Onishchenko mal y pense.” (Honi soit qui mal y pense. I simply have no idea what that’s about; if bicalutamide has been publicly suggested as a repurposed drug for the pandemic, I’ve certainly missed seeing it. But wouldn’t a 60 mg dose provide 5 or at least ~ 3.5 times as much concentration? It would be interesting if its anti-inflammatory effect makes Ivermectin helpful. Too good to be true. The great about this is the money you can save. Large grain of NaCl required for this one, but for me it would be really cool if ivermectin worked. It left behind fake hopes with 18 clinical trials and a 404 code. Puede darle una vista a esta liga? Never heard it described that way. SIXTY EIGHT. This was true even when they were also ill with suspected salmonella and with protein losing enteropathy. . Martin: Do you really need twelve gallons? Scabies is a skin disease caused by infestation with the mite Sarcoptes scabiei . Use with caution for collies and other herding dog breeds. What about the doctors from Bangladesh who have seen remarkable results using Ivermectin along with Doxycycline? The bottom line is…. One of the small-molecule drugs that’s getting attention as a possible coronavirus treatment is Ivermectin, which is an interesting story from a couple of different directions. Vaccination can be done in the village, worldwide. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. Did they never bother to check on the lit. SAFETY No money in it, that’s the bottom line. Dog Weight Tablets Ivermectin Pyrantel setTimeout( The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated. See Comfortis label for complete safety information. Strong anti inflammatory response that was vital to healing. No problem at all though. He never, ever had an issue. Protect product from light. A: Only by the bite of an infected mosquito. on blood concentrations of the drug. These are also supersaturating ivermectin concentrations for culture media, too. Just wanted to say thank you, I’ve been fascinated by that study for a while, and was wondering if there is an explanation for how the results might be spurious. I think the thing to keep in mind here is — the bar for success is not “cure,” it’s not “wiping out virus in 2 hours.” The bar for success right now is ANYTHING THAT HELPS EVEN A LITTLE. Who reviewed these trial proposals? We all have seen how industrial face mask and even ordinary bandanas became “medical devices” overnight, unverified tests allowed for wide usage, hydroxycloroquine and others fast tracked for coronavirus. The article you linked (“Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?” Maclean et al., Parasit Vectors. The smallpox virus (variola) was eradicated because there are no animal reservoirs – its solely a human pathogen. Ivermectin is too important to be ignored and more research should be initiated to reap the benefits of having a cheap and safe means to deal with Covid-19 while the world awaits development of more effective drugs and vaccines. Hcq was never a problem before it got politicized. …Why would any sane doctor who is trying to help his patients use a “double-blind test” …or any other test, when ivermectin just cures the patient in two to 5 days ? Are there black box warnings for veterinary drugs? I have been reading this article and everyone’s comments with great interest. The Vetbiochem Group has operations in many countries with its head-quarters based in Moscow, Russia. Hopkins dropped the ivermectin arm of their trial. They compared people who, in recent weeks, have received Ivermectin to another group, of equal size that involves people who started getting ill back in January. Yea, that makes me much more pessimistic regardless of the dose they administer. The UK recovery trial has provided some clarity. Never have I had a positive heart worm test on my labradors. Martin: Good morning. An international, multicenter, observational propensity-score matched case-controlled study using prospectively collected data on patients diagnosed with COVID-19 between January 1, 2020 and March 31, 2020. Professor Thomas Borody from Australia is reporting fantastic results from a study in California when Ivermectin is combined with Zinc and Doxycycline – 100% cure rate with minimal side effects. what does “Large grain of NaCl required for this one” mean please? I have 4 dogs and this heartworm prevention I have been using for years and my fur kids have never tested positive for heart worm. One doctor does claim “remarkable” results with Ivermectin added to the HcQ+Zpak+Zn 3-pack. Basic research on the mechanism of action of ivermectin in the cell culture and animal model should be investigated urgently. The oxygens coordinate Lithium ions better, which is good for many folks in this blog who seem to experience a manic episode. And I haven’t seen statistics on whether obesity-without-diabetes is a risk factor, but it doesn’t look like as much of a risk factor as the media keep saying – and fat cells make estrogen (converting it from testosterone). Listen to the scientist speaking starting at about the 18th minute: David: I listened to that the first time you posted it. The comparison group goes back to January first. A related group of compounds, without the carbohydrates on the side, are the milbemycins. 1 Excursions between 59°F-86°F (15°-30°C) are permitted. I rescue horses and the wormer recommended by my vets was one that by my observation was more likely to kill very poor animals with a high worm burden. Hi I am not a doctor but recently there was some data published with respect to data from clinical trials using ivermectin of which the results proved to be very effective. Furthermore, the drug is widely used in the veterinary. But it has been shown several times to have activity in cell assays against Dengue infection and to reduce viral loads in the mosquito vectors (see this paper and references therein), although the reasons for this are still unknown. In fact, just yesterday there was news that Gilead contracted with about 5 other pharma manufactuers to make Remdesivir. The world today has 6.8 billion people. Thank you. Yes they too politicized a pandemic. 5 This site uses Akismet to reduce spam. I was nervous my picky dogs wouldn't eat these like they do with the regular Heartgard. No science background here but when the Monash study first made the news, I looked up which countries take Ivermectin for River Blindness and checked their mortality rate for C19. The ICON trial at several hospitals in south Florida Good thing many of the poor people cured and saved by Ivermectin in Peru, Brazil, Dominican Republic etc were not knowledgeable enough to have their “all knowing wisdom and self-grandiose stand in the way of pursuing an “anecdotal” snake oil! Barring that, it’s still really really hard to know the local concentration at the target. Yes, but did they test it in the presence of Zinc? It was not a randomized study. This is the same problem with the Didier Raoult study. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Well, there is a four arm study underway in Egypt, three of the arms including Ivermectin combined with another drug, with a completion date estimated to be in the year 2030. I was in a group that was working on the synthesis of Ouabain and Sarain A. In dimly remembered mathspeak, a magnitude is arithmetic, it is a change in a value by one power of x in base x; an order is functional analysis, it is the behaviour of a function (e.g. I’m an ex-grazier that use ivermectin on the farm way back… This Brazilian doctor says that the disease has fases and she treats every patient differently depending in the fase. You are all very kind to expend any energy at all on pointing them toward facts and reality, or by politely ignoring them. We simply can’t wait a year for a vaccine – especially when a lot of commentators doubt whether a vaccine is even possible for this one. https://clinicaltrials.gov/ct2/results?cond=COVID-19&term=ivermectin&cntry=&state=&city=&dist=. A group at Monash Univ. b) But we hear reports of anecdotal miraculous improvements http://ssrn.com/abstract=3580524) was done by the same authors and using the same methodology as the negative hydroxycloroquine study recently published in Lancet [Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. HeartShade Plus (ivermectin/pyrantel) Tablets, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. Caffeine has also been found to enhance the reward memory of honey bees. The last thing that they want is to include zinc, which is actually the active part of the cure as zinc interferes with the RNA viruses trying to hijack the ribosomes. The best for less! Ivermectin produced far better results. I think that it is very possible that this study is severely flawed in making comparison to outcomes in the past 3 weeks compared to outcomes several months ago. This link discusses the dosage disparity between approved use vs covid-19 requirements fairly well. Ivermectin paste is a super wormer that provides a broad spectrum of protection, with FDA approval to treat and control many species and stages of parasites, bots, strongyles, and more. Thank you for keeping the cost down. Plenty of time during the lockdown to learn something new! Gosh, don’t they know anything? The individual speaking at that point in the recording is talking about how you would go about dose escalation in a clinical trial basically addressing safety. Then there is the University of Kentucky’s trial, another four arm, recruiting 280 patients, with one of the arms including Ivermectin combined with Hydroxychloroquine. ADMINISTRATION + I wouldn’t be surprised if “non-suitable for human” grade ivermectin, suddenly become absolutely “approved”. She has all the protocols published on her instagram and will start to be released soon to all doctors in Brazil, please check I tried to translate but ididnt Because it’s like a photo. Sorry-my comment somehow didn’t get pasted in. Thus in general oral ivermectin appears to have little toxicity in the dose range that would be needed to approach a serum concentration of ~ 2 microM. The rest of the structure falls into the “doable with time and effort” category – the rest of the ring structure down there, the spiroketal in the northeast, the macrolide polyene ring, and the glycosyls coming off of it. He refers to positive results in the Dominican Republic, and Peru and refers to a paper: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3580524 that seems very compelling. })(120000); If the molecular weight is 875, then 875 nanograms/ml is 1 micromolar. (18mg) course was 2 days. The boss let me borrow his copy, but I eventually got my own copy. Yeah, it’s not the kind of gap one is used to seeing! Also, check out the latest study out of Argentina showing great results using Ivermectin as a preventative – 1,195 hospital staff participated. I recall spending time a few years ago looking into improved loaisis diagnostics. Everyone knows that the oleandrose side chains and spiroketal forms a dimeric metal coordination site that serves as an ionophore for zinc!” Really? Severe headache and breathing problems were gone in one dose. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. It does distribute strongly out into tissue, though, and that combined with its intrinsically high activity against the roundworms does the job. My first task (in 1988) was to sequence the genes for the aglycone portion of the molecule. And it appears to have indirectly reduced the average number of children per family. Rattlesnake Bites in California . There it was tried IN VIVO and it was only administered once! There is a report in media where a doctor in Bangladesh has treated 60 patient with ivermectine and Doxycycline . I checked the label and it doesn’t contain any breed-related warnings. Does anyone know where these pills are manufactured? Which is correct? Maybe the key to the Marseille protocol isn’t the HCQ, it’s the AZI….. I’m sure the Poincare paper will be ignored in the US by a scientific community that’s emotionally invested in seeing HCQ fail, and also because there’s no $100 billion California biotech out there going to lobby Washington on behalf of a 6 cent pill. Be cool… hand-waving, because who knows what the pharmacokinetics do as you jack up dosing. 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